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| DXN CORDYCEPS |
Cordyceps sinensis,
the Cordyceps species most widely used as a dietary supplement,
naturally grows on the back of the larvae of a caterpillar from the
mothHepialus armoricanus Oberthur found mainly in China, Nepal, and
Tibet. The mycelium invades the caterpillar and eventually replaces
the host tissue. The stroma (fungal fruit body) grows out of the top of
the caterpillar. The remaining structures of the caterpillar along with the
fungus are dried and sold as the dietary supplement cordyceps.
Commonly known as “dong chong
xia cao” (summer-plant, winter-worm) in Chinese, cordyceps has been used as a
tonic food in China and Tibet and has been used as a food supplement and tonic
beverage among the rich because of its short supply due to over harvesting. It
is also an ingredient in soups and other foods used traditionally in Chinese
medicine for thousands of years helping debilitated patients recover from
illness.
Although written record
of Cordyceps sinensis use appeared in Traditional Chinese
Medicine centuries ago, it wasn’t really noticed in the West until recently.
The last two decades have seen a great increase in research on cordyceps as a
medicinal mushroom.
There
are many reported cordyceps health benefits. Some
of these include:
·
Cholesterol reduction
·
Stimulation of the immune
system
·
Faster recovery from bronchitis
and respiratory diseases
·
Increased efficiency and
stamina of the circulatory system
·
Anti-tumor properties
·
Liver protection and enhanced
recovery from chemotherapy
·
Sexual issues make active strongly
and long timing
·
A general body adaptogen,
resulting in more energy, strength, and stamina the reasons behind some of these benefits are still not
fully understood. Yet research has found some promising proof behind cordyceps
claims. A few of the helpful constituents found are:
Sterols – Alcohols of the
steroid group. Believed to lower cholesterol, reduce the risk of heart disease,
and possibly have some anti-tumor properties.
Polysaccharides – Complex
carbohydrates made up of chains of sugars. Known to stabilize blood pressure,
have an effect on free radicals, and stimulate the immune system.
Nucleosides – Organic molecules that are the converted into building blocks of the genetic material DNA and RNA. Nucleoside drugs are sometimes used to treat cancer.
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One of the most useful things
thatCordyceps sinensis appears to do is the simple act of
oxygenation. The fungus dilates the airways in the lungs, resulting in
more oxygen to the blood. Thus more oxygen reaches every cell of the body,
resulting in better cell function and greater energy levels.
Cordyceps is used therapeutically
for asthma, bronchitis,
chemoprotection, exerciseperformance, hepatitis B, hepatic
cirrhosis, hyperlipidemia (high cholesterol), as animmunosuppressive
agent, and in chronic renal failure.
The fungus became popular in
1993 when two female Chinese athletes, who admitted using cordyceps
supplements, beat the world records in the track and field competition at the
Stuttgart World Championships for the 1,500-, 3,000-, and 10,000-meter runs.
The women were drug tested for any banned substances such as steroids and were
negative. Their coach attributed the performance to the cordyceps
supplementation.
POTENTIAL HEALTH BENEFITS OF
CORDYCEPS
Hepatitis B:
Cordyceps may stimulate the
immune system and improve serum gamma globulin levels in hepatitis B patients.
Currently, there is insufficient evidence to recommend for or against the use
of cordyceps for chronic hepatitis B. However, the results are promising.
Additional study of cordyceps and current hepatitis treatments is needed.
Hyperlipidemia
(high cholesterol):
Cordyceps may lower total
cholesterol andtriglyceride
levels, although these changes may not be permanent or long lasting.
Longer studies with follow up are needed to determine the long-term effects of
cordyceps on hyperlipidemia.
Anti-aging:
Cordyceps may improve various
symptoms related to aging. However, higher quality studies testing specific
symptoms of aging are needed before the effects of cordyceps can be described.
Currently, there is insufficient evidence to recommend for or against the use
of cordyceps for anti-aging.
Asthma:
Cordyceps may reduce some
asthma symptoms. Additional studies are needed to make a firm
recommendation.
Bronchitis:
There is insufficient evidence
from controlled clinical trials to recommend for or against the use of
cordyceps for bronchitis. Most studies using cordyceps have found improved
symptoms with cordyceps more than the control drugs. Although results are
promising, more studies should be performed before a firm recommendation can be
made.
Chemoprotective:
There is insufficient evidence
to recommend for or against the use of cordyceps as a chemoprotective agent
in aminoglycoside toxicity. However, the results are promising.
Exercise
performance enhancement:
In 1993, two female Chinese
athletes, who admitted using cordyceps supplements, beat the world records in
the track and field competition at the Stuttgart World Championships for the
1,500-, 3,000-, and 10,000-meter runs. However, there is insufficient evidence
from conflicting controlled clinical trials to recommend for or against the use
of cordyceps for improving exercise performance. More studies are needed in
this area.
Immunosuppression:
Two studies using combination
herbal treatments that included cordyceps indicate that these combinations suppressed
the immune system in kidney
transplant and lupus
nephritis patients. However, as these treatments used
combination products, the effect of cordyceps cannot be defined. More studies
with cordyceps as a monotherapy are needed.
Liver
disease (hepatic cirrhosis):
In traditional Chinese
medicine, cordyceps has been used to support and improve liver function. In two
studies using herbal combinations that included cordyceps, liver function
improved liver and immune function. However, as these studies used combination
treatments, the effect of cordyceps alone is unknown.
Renal
failure (chronic):
In traditional Chinese
medicine, cordyceps is used to strengthen kidney function. Two studies indicate
that cordyceps may improve renal function in patients with chronic renal
failure. More studies are needed to confirm these findings.
Diabetes. Cordyceps
may benefit people at risk of diabetes. Researchers from University of Macau,
China, isolated a
polysaccharide of molecular weight approximately 210kDa was isolated from
cultured Cordyceps mycelia. This isolated polysaccharides, CSP-1, has a
strong antidant activity and a hypoglycemic effect on normal and
alloxan-diabetic mice and streptozotocin (STZ)-diabetic rats. When
administered at a dose of higher than 200mg/kg body wt. daily for 7
days, CSP-1 produced a significant drop in blood glucose level in both
STZ-induced diabetic rats and alloxan-induced diabetic mice.
Researchers from China Agricultural University,
Beijing, also noticed the blood glucose lowering effects of
a polysaccharide extracted from the fruting bodies and mycelia of
Cordyceps militaris in a study of rats. The hypoglycemic effect of this
polysaccharide-enriched Cordyceps militaris extract was dose-dependent. Korean
researchers showed a water-extract of Cordyceps militaris ameliorated
insulin resistance by enhancing glucose utilization in skeletal muscles of
rats.
Anti-oxidative Activities Cordyceps
has antioxidant activities. Researchers from Chia Nan University of Pharmacy
and Science,
Taiwan, demonstrated the protective effects of cultured Cordyceps militaris and
natural Cordyceps sinensis against oxidative damage of biomolecules in a
vitro study. They both have free radical scavenging abilities.
Cancer Cordyceps
may offer benefits to those suffered from certain cancers. The aqueous extract
of Cordyceps sinensis (Cs), one of the traditional Chinese medicines, has
been demonstrated to benefit a wide range of disorders in either animal or test-tube
studies. Here are some most recent animal or in vitro studies suggesting its
benefits in cancers.
Korean researchers reported cytotoxic effects of
cultivated fruiting bodies of Cordyceps militaris extracts against
the proliferation of the human premyelocytic leukemia cell HL-60 via the
activation of caspase-3.
Researchers from Nanjing University shouls that a
polysaccharide extracted from a cultivated Cordyceps sinensis
fungus significantly enhanced superoxide dismutase activity of liver,
brain and serum as well as glutathione peroxidase activity of liver and
brain in tumor-bearing mice. It also inhibited H22 tumor growth in the mice.
Hong Kong researchers demonstrated that an
ethanol extract of cultivated mycelium of a Cordyceps
sinensis fungal mycelium has strong anti-tumor activity on
four cancer cell lines MCF-7 breast cancer, B16 mouse melanoma,
HL-60 human premyelocytic leukemia and HepG2 human hepatocellular
carcinoma. In an animal test, the EtOAc extract showed significant inhibiting
effect on B16-induced melanoma in C57BL/6 mice, causing about 60% decrease of
tumor size over 27 days. In contrast, this extract had much lower
cytotoxicity against normal mouse bone marrow cells.
Cordyceps sinensis is believed to be an
immunomodulator. Hong Kong researchers demonstrated that a cultivated strain of
Cordyceps sinensis induced the production of interleukin (IL)-1beta, IL-6,
IL-10 and tumor necrosis factor alphaalpha from PBMC, augmented surface
expression of CD25 on lymphocytes in a vitro study. While, researchers from
Zhejiang University, China, desmonstrated increased ovalbumin-specific IgG,
IgG1 and IgG2b serum levels after treating the mice with edible mycelia of
Cordyceps sinensis.
A rat study has shown that a Cordyceps sinensis
mycelium extract protected mice from group A streptococcal infection.
It increased IL-12 and IFN-gamma expression and macrophage phagocytic
activities.
Memory Cordyceps
may benefit people suffered from memory deficits. The extract of Cordyceps
ophioglossoides protected the Abeta-induced neuronal cell death and memory
loss through free radical scavenging activity.
Cholesterol Profiles
Cordyceps may benefit people with cholesterol-lowering effects. In
a study, researchers fed mice with cholesterol-
enriched diet. They found that the serum total cholesterol (TC) of all mice
groups administered Cordyceps sinensis
extracts with the cholesterol-enriched diet decreased more than in the control
group.
Heart and Circulation Issues Cordyceps
may offer benefits of cardiovascular protection. Extracts of the fruiting
bodies of cultured Cordyceps sinensis has been shown to exert beneficial
effects on the formation of the atherosclerotic lesion induced by oxidative
stress with few side effects in a study of mice. In the study, researchers
fed mice with an atherogenic diet and treated with the extracts for 12
weeks. Mice fed the atherogenic diet showed marked increases in serum lipid and
lipid peroxide levels and also aortic cholesterol levels, particularly
cholesteryl ester level, a major lipid constituent in atherosclerotic
lesions. According to the authors, the extracts significantly suppressed
the increased serum lipid peroxide level but not other lipid levels in a
dose-dependent manner. WECS also suppressed the increased aortic cholesteryl
ester level in a dose-dependent manner.
Researchers isolated a macromolecule from Cordyceps
sinensis and they found this molecule has blood pressure lowering and
vaso-relaxing effects. The researchers explained that the vasorelaxation was
mediated by the endothelium possibly by stimulating the release of the
nitric oxide and endothelium-derived hyperpolarizing factor.
OTHE Cordyceps
may also have beneficial effects on kidney, but, more studies are needed to
understand the mechanism. CLINICAL STUDIES ARE NEEDED
TO SUPPORT THESE CORDYCEPS BENEFITS.
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